Pharmacogenetics of Carbamazepine: A Systematic Review on CYP3A4 and CYP3A5 Polymorphisms.

Rachda Riffi Wefa Boughrara Amina Chentouf Wassila IliasNarimene Malika Taieb IbrahimAmel Alioua Berrebbah Fatma Belhocine

Published in: CNS & neurological disorders drug targets (2024)

Although these findings highlight the impact of genetic variations in the CYP3A4 and CYP3A5 genes on CBZ pharmacokinetics and pharmacodynamics, further studies across diverse populations are essential to enhance personalized epilepsy therapy in clinical settings.

Keyphrases

genome wide
dna methylation
copy number
case control
stem cells
gene expression
mesenchymal stem cells