Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart.
Hirad A FeridooniJennifer K MacDonaldAnjali GhimireW Glen PyleSusan E HowlettPublished in: American journal of physiology. Heart and circulatory physiology (2016)
We investigated myocardial effects of acute application of progesterone. In females, but not males, progesterone attenuates and slows cardiomyocyte contraction with no effect on calcium transients. Progesterone also reduces myofilament calcium sensitivity in female hearts. This may adversely affect heart function, especially when serum progesterone levels are high in pregnancy.Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/acute-progesterone-modifies-cardiac-contraction/.
Keyphrases
- liver failure
- estrogen receptor
- respiratory failure
- left ventricular
- heart failure
- drug induced
- aortic dissection
- smooth muscle
- atrial fibrillation
- pregnant women
- preterm birth
- intensive care unit
- endothelial cells
- mass spectrometry
- extracorporeal membrane oxygenation
- angiotensin ii
- atomic force microscopy
- high glucose
- high speed