Maternal total cell-free DNA in preeclampsia and fetal growth restriction: Evidence of differences in maternal response to abnormal implantation.

Tal Rafaeli-YehudaiMajdi ImteratAmos DouvdevaniDan TiroshNeta Benshalom-TiroshSalvatore Andrea MastroliaRuthy Beer-WeiselVered KlaitmanReut RiffShirley GreenbaumAlex AlioshinGal Rodavsky HanegbiGiuseppe LoverroMariana Rita CatalanoOffer Erez

Published in: PloS one (2018)

Preeclampsia is associated with higher maternal serum t-cfDNA concentration than normal pregnancy or FGR. This observation may reflect an increased systemic activation of the maternal inflammation, rather than placental; this assumption is supported by the fact that we did not observe a significant change in the maternal serum t-cfDNA in patients with placental-mediated FGR.

Keyphrases

pregnancy outcomes
birth weight
pregnant women
early onset
oxidative stress
preterm birth
weight loss
drug induced