Even a low dose of tamoxifen profoundly induces adipose tissue browning in female mice.
Liang ZhaoBo WangNoe Alberto GomezJeanene M de AvilaMei-Jun ZhuMin DuPublished in: International journal of obesity (2005) (2019)
Tamoxifen, even at a low dose, remarkably increases thermogenesis in adipose tissues of female mice; meanwhile, such a low dose could be used in male mice for inducing gene recombination without confounding the interpretation of data related to metabolism and thermogenesis of adipose tissues.
Keyphrases
- adipose tissue
- low dose
- high fat diet induced
- insulin resistance
- high dose
- high fat diet
- gene expression
- breast cancer cells
- estrogen receptor
- positive breast cancer
- genome wide
- dna damage
- electronic health record
- dna repair
- type diabetes
- dna methylation
- skeletal muscle
- metabolic syndrome
- big data
- wild type
- drug induced
- artificial intelligence
- genome wide analysis