A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H2S) Donor with Self-Reporting Fluorescence.
Ning ZhangPing HuYanfang WangQing TangQiang ZhengZhanlong WangYun HePublished in: ACS sensors (2020)
Hydrogen sulfide (H2S) is an important cellular signaling molecule, and its physiological and pathophysiological properties have been under intensive investigation. In this study, a novel ratiometric fluorescent H2S donor (HSD-B) has been developed, which exhibited the following advantages: (i) scavenging ROS and producing H2S simultaneously; (ii) providing ratiometric fluorescence for visualization and quantification of H2S releasing; and (iii) targeting mitochondrion specifically. Moreover, it demonstrated protective effects on myocardial ischemia reperfusion injury in a cellular model. These attractive features promise this HSD-B as a fluorescent H2S donor for future research studies.
Keyphrases
- reactive oxygen species
- living cells
- quantum dots
- single molecule
- energy transfer
- fluorescent probe
- sensitive detection
- cell death
- dna damage
- hydrogen peroxide
- left ventricular
- nitric oxide
- big data
- heart failure
- emergency department
- machine learning
- label free
- electronic health record
- atrial fibrillation
- electron microscopy