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Identification and functional analysis of a novel G310D variant in the insulin-like growth factor 1 receptor (IGF1R) gene associated with type 2 diabetes in American Indians.

Yunhua L MullerGraham SkeltonPaolo PiaggiPeng ChenAnup NairSayuko KobesWen-Chi HsuehWilliam C KnowlerRobert L HansonLeslie J BaierClifton Bogardus
Published in: Diabetes/metabolism research and reviews (2018)
A unique G310D variant in IGF1R, which occurs in 6% American Indians, may impair IGF1R signalling pathways, thereby increasing the risk of T2D.
Keyphrases
  • growth hormone
  • type diabetes
  • binding protein
  • pi k akt
  • genome wide
  • glycemic control
  • metabolic syndrome
  • gene expression
  • dna methylation
  • adipose tissue
  • skeletal muscle
  • bioinformatics analysis