Facile Synthesis of the Cu, N-CDs@GO-CS Hydrogel with Enhanced Antibacterial Activity for Effective Treatment of Wound Infection.
Mingqian WangAo XiaShishan WuJian ShenPublished in: Langmuir : the ACS journal of surfaces and colloids (2021)
Drug resistance and increasing dangers during antibiotic treatment have brought a new eternal task for the research of effective antibacterial agents or therapeutics. In this work, we used Cu, N-doped carbon dots (Cu, N-CDs) to modify graphene oxide (GO) nanosheets and then loaded to chitosan (CS) hydrogels via electrostatic interaction to form Cu, N-CDs@GO-CS hydrogel nanoplatforms to treat Staphylococcus aureus and Escherichia coli. The excellent antibacterial activity is from the combined effects of hyperthermia and reactive oxygen species generated under near-infrared (NIR) laser irradiation of the Cu, N-CDs@GO-CS hydrogel, which shows excellent antibacterial activity compared with the CS hydrogel or the Cu, N-CDs@GO-CS hydrogel without NIR laser irradiation. Moreover, the inherent antibacterial nature of the CS hydrogel or the Cu, N-CDs@GO-CS hydrogel was used to treat bacteria-infected wounds in mice, which also protected the wound area from second infection. In vivo experiments demonstrate favorable wound healing results and have no significant harmful side effects to the major organs in mice. Overall, this work demonstrates that the antibacterial Cu, N-CDs@GO-CS hydrogel offers significant prospect as an antibacterial reagent for wound healing.
Keyphrases
- wound healing
- quantum dots
- drug delivery
- metal organic framework
- visible light
- aqueous solution
- escherichia coli
- staphylococcus aureus
- silver nanoparticles
- hyaluronic acid
- reactive oxygen species
- type diabetes
- adipose tissue
- drug release
- skeletal muscle
- metabolic syndrome
- molecular dynamics simulations
- combination therapy
- tissue engineering
- highly efficient
- multidrug resistant