In-silico Studies, Design, and Synthesis of Pyrimidine-linked Benzothiazoles for its Anticonvulsant Potential.

Amol Kale Rajendra Kakde Smita Pawar Rutuja ThombareDhanashree ZopeIshwar Kakde

Published in: Current drug discovery technologies (2024)

Thus, the compounds BPD-15 and BPD-5 have shown a considerable affinity towards the sodium channel as compared to the standard drug Riluzole. Compound BPD-14 showed good drug compatibility, and compounds BPD-1, BPD-2, BPD-11, BPD-12, BPD-13, BPD-14, BPD-15 showed good ADME values.

Keyphrases

molecular docking
risk assessment
molecular dynamics simulations
capillary electrophoresis