Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma.
Noemí PuigJuan A Flores-MonteroLeire BurgosMaría-Teresa CedenaLourdes CordónJosé-Juan PérezLuzalba Sanoja-FloresIrene ManriquePaula Rodríguez-OteroLaura RosiñolJoaquin Martinez LopezMaria-Victoria Mateos-MantecaJuan-José LahuertaJoan BladéJesús San F MiguelAlberto OrfaoJuan José LahuertaPublished in: Cancers (2021)
Our study supports the routine assessment of BM cellularity to evaluate hemodilution, since reduced BM-specific cell types as compared to reference values (either treatment-specific or from HA if the former are unavailable) could indicate hemodilution and a false-negative MRD result.