Gut microbiome signatures of nursing home residents carrying Enterobacteria producing extended-spectrum β-lactamases.

Quentin Le BastardGuillaume ChapeletGabriel BirgandBenjamin M HillmannFrançois JavaudinNiki HayatgheibCéline BourigaultPascale BemerLaure De DeckerEric BatardDidier LepelletierEmmanuel Montassier

Published in: Antimicrobial resistance and infection control (2020)

The gut microbiome of ESBL-E carriers in nursing homes harbors specific taxonomic and functional characteristics, conferring an environment that enables Enterobacteriaceae expansion. Here we describe new functional features associated with ESBL-E carriage that could help us to elucidate the complex interactions leading to colonization persistence in the human gut microbiota.

Keyphrases

klebsiella pneumoniae
escherichia coli
endothelial cells
multidrug resistant
pseudomonas aeruginosa
gene expression
dna methylation
cystic fibrosis