C5aR1 signaling promotes region and age dependent synaptic pruning in models of Alzheimer's Disease.

Angela Gomez-ArboledasMaria I FonsecaEnikö KramarShu-Hui Chu Nicole D Schartz Purnika SelvanMarcelo A WoodAndrea J Tenner

Published in: bioRxiv : the preprint server for biology (2023)

Reduction of excessive synaptic pruning is an additional beneficial outcome of the suppression of C5a-C5aR1 signaling, further supporting its potential as an effective targeted therapy to treat AD.

Keyphrases

prefrontal cortex
cognitive decline
physical activity
body mass index
weight loss