Display of malaria transmission-blocking antigens on chimeric duck hepatitis B virus-derived virus-like particles produced in Hansenula polymorpha.

David WetzelJo-Anne ChanManfred SuckowAndreas BarbianMichael WenigerVolker JenzelewskiLinda ReilingJack S RichardsDavid A AndersonBetty KouskousisCatherine PalmerEric HanssenGerhard SchembeckerJuliane MerzJames G BeesonMichael Piontek

Published in: PloS one (2019)

The incorporation of leading Plasmodium falciparum transmission-blocking antigens into the dS-based VLP scaffold is a promising novel strategy for their display on nano-scaled particles. Competitive processes for efficient production and purification were established in this study.

Keyphrases

plasmodium falciparum
hepatitis b virus
dendritic cells
liver failure
cell therapy
stem cells
tissue engineering
recombinant human