Triazol-phenyl Antipyretic Derivatives Inhibit mPGES-1 mRNA Levels in LPS-Induced RAW 264.7 Macrophage Cells.

Lenisa Dandara Dos SantosThamires Quadros FroesMiriam Cristina Contin de MeloGloria Emília Petto de SouzaDenis de Melo SoaresMarcelo Santos Castilho

Published in: Anti-inflammatory & anti-allergy agents in medicinal chemistry (2022)

PGE2 concentration reduction in the hypothalamus, due to compound 1 central injection, is related to decreased mPGES-1 mRNA levels but not to COX-2 inhibition (IC50> 50 μM). Therefore, compound 1 is a promising lead for innovative antipyretic drug development.

Keyphrases

lps induced
inflammatory response
induced apoptosis
cell cycle arrest
adipose tissue
oxidative stress
endoplasmic reticulum stress
cell death
ultrasound guided