METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.

Peng XiaHao ZhangHaofeng LuKequan XuXiang JiangYuke JiangXiangdong GongyeZhang ChenJie LiuXi ChenWeijie MaZhonglin ZhangYufeng Yuan

Published in: Cancer communications (London, England) (2023)

These findings point to a novel mechanism by which CREB1/P300-METTL5-USP5-c-Myc controls abnormal glucose metabolism and promotes tumor growth, suggesting that METTL5 is a potential therapeutic target and prognostic biomarker for HCC.

Keyphrases

human health
risk assessment