CD117 immunoexpression in oral and sinonasal mucosal melanoma does not correlate with somatic driver mutations in the MAPK pathway.

Jessica Maldonado-MendozaVelia Ramírez-Amador Anaya-Saavedra GabrielaErika Ruíz-GarcíaHéctor Maldonado-MartínezEdith Fernández FigueroaAbelardo Meneses-García

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)

Regardless of the high immunoexpression of C-KIT, there was no association with the MAPK mutations among POSNM samples. Thus, C-KIT immunohistochemistry is not a reliable tool to detect POSNM candidates for biological therapy.

Keyphrases

signaling pathway
oxidative stress
pi k akt
copy number
cell proliferation
skin cancer
basal cell carcinoma