CD117 immunoexpression in oral and sinonasal mucosal melanoma does not correlate with somatic driver mutations in the MAPK pathway.
Jessica Maldonado-MendozaVelia Ramírez-AmadorAnaya-Saavedra GabrielaErika Ruíz-GarcíaHéctor Maldonado-MartínezEdith Fernández FigueroaAbelardo Meneses-GarcíaPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)
Regardless of the high immunoexpression of C-KIT, there was no association with the MAPK mutations among POSNM samples. Thus, C-KIT immunohistochemistry is not a reliable tool to detect POSNM candidates for biological therapy.