Eltrombopag increases the hematopoietic supporting ability of mesenchymal stem/stromal cells.

Sandra MuntiónSilvia PreciadoElena Sánchez-LuisLuis CorcheteMaría Díez-CampeloLika OsuguiGerardo-Javier Martí-ChillónMaría-Belén VidrialesAlmudena Navarro-BailónJavier De Las RivasFermin M Sanchez-Guijo

Published in: Therapeutic advances in hematology (2022)

Our findings support the use of EP in cases where hematopoiesis is defective, despite its well-known direct effects on hematopoietic cells. Our findings suggest that further studies on the effects of EP on MSCs from patients with aplastic anemia are warranted.

Keyphrases

bone marrow
induced apoptosis
mesenchymal stem cells
cell cycle arrest
stem cells
chronic kidney disease
cell death
endoplasmic reticulum stress
oxidative stress
iron deficiency
cell proliferation
pi k akt