Structural Evaluation and Conformational Dynamics of ZNF141 T474I Mutation Provoking Postaxial Polydactyly Type A.

Yasir AliFaisal AhmadMuhammad Farhat UllahNoor Ul HaqM Inam Ul HaqAbdul AzizFerjeni ZouidiMuhammad Ijaz Khan ElSayed M Tag El Din

Published in: Bioengineering (Basel, Switzerland) (2022)

This study provides molecular insights into the structural association of ZNF141 protein with PAP type A. Identification of active site residues and legends offers new therapeutic targets for ZNF141 protein. Further, it reiterates the functional importance of the last residue of a protein.

Keyphrases

amino acid
protein protein
binding protein
molecular dynamics
small molecule
molecular dynamics simulations