The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer.

Emanuela BrunettoLucia De MonteGianpaolo BalzanoBarbara CamisaVincenzo LainoMichela RibaSilvia HeltaiMarco BianchiClaudio BordignonMassimo FalconiAttilio BondanzaClaudio DoglioniMaria Pia Protti

Published in: Journal for immunotherapy of cancer (2019)

Our findings indicate that tumor released IL-1α and IL-1β and ASC are key regulators of TSLP secretion by CAFs and their targeting should ultimately dampen Th2 inflammation and improve overall survival in pancreatic cancer.

Keyphrases

oxidative stress
transcription factor
single cell
nlrp inflammasome
cell therapy
cancer therapy
mesenchymal stem cells