A Novel Prognostic Signature Revealed the Interaction of Immune Cells in Tumor Microenvironment Based on Single-Cell RNA Sequencing for Lung Adenocarcinoma.

Xing Jin Zhengyang Hu Qihai Sui Mengnan Zhao Jiaqi Liang Zhenyu Liao Yuansheng Zheng Hao Wang Yu Shi

Published in: Journal of immunology research (2022)

Our observations implied that immune cells played a pivotal role in TIME and established a 5-gene signature (including IDH2, ADRB2, SFTPC, CCDC69, and CCND2) on the basement of nature killer markers targeted by WGCNA analysis. The significance of clinical outcome and immunotherapy response prediction was validated robustly.

Keyphrases

single cell
rna seq
high throughput
copy number
cancer therapy
genome wide
data analysis