Carbapenem resistance in Acinetobacter pittii isolates mediated by metallo-β-lactamases.
Alexander WunderlichKyriaki XanthopoulouJulia WilleEsther WohlfarthStefanie GersonMartin KaaseHarald SeifertPaul G HigginsPublished in: The Journal of antimicrobial chemotherapy (2022)
These data show the existence of a promiscuous plasmid circulating in A. pittii isolates in Germany that differs only in the MBL-encoding region. Its plasmid backbone has been found globally among multiple Acinetobacter spp. These data should raise awareness of an epidemic conjugative plasmid that has independently acquired MBLs. We should also consider that future comparative plasmid analysis will look beyond solely the resistome and include the mobile elements carrying the resistance genes.
Keyphrases
- escherichia coli
- crispr cas
- acinetobacter baumannii
- electronic health record
- klebsiella pneumoniae
- multidrug resistant
- drug resistant
- genetic diversity
- genome wide
- pseudomonas aeruginosa
- machine learning
- dna methylation
- gene expression
- data analysis
- microbial community
- antibiotic resistance genes
- cystic fibrosis
- transcription factor