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NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia.

Chun-Chun WeiYuan-Yuan KongXia HuaGuo-Qiang LiSi-Li ZhengMing-He ChengPei WangChao-Yu Miao
Published in: British journal of pharmacology (2017)
Our results demonstrate that NMN ameliorates tPA-induced haemorrhagic transformation in brain ischaemia by maintaining the integrity of the BBB.
Keyphrases
  • blood brain barrier
  • cerebral ischemia
  • high glucose
  • diabetic rats
  • drug induced
  • subarachnoid hemorrhage
  • white matter
  • oxidative stress
  • brain injury
  • resting state