Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects.
Maialen AldabaldetrecuLaura TamayoRomina AlarconMariana WalterEdison Salas-HuenuleoMarcelo J KoganJuan GuerreroMaritza PaezManuel Ignacio AzócarPublished in: Molecules (Basel, Switzerland) (2018)
The antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences. Four effects of the Ag-complexes were evidenced by transmission electronic microscopy (TEM) and scanning electronic microscopy (SEM): DNA condensation, membrane disruption, shedding of cytoplasmic material and silver compound microcrystal penetration of bacteria. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity. However, Ag-5Cl was the most stable against exposure UV light (365 nm). Cytotoxic effects were tested against two kinds of eukaryotic cells: murine fibroblast cells (T10 1/2) and human epithelial ovarian cancer cells (A2780). The main objective was to identify changes in their antibacterial properties associated with potential decomposition and the implications for clinical applications.
Keyphrases
- silver nanoparticles
- anti inflammatory
- gold nanoparticles
- induced apoptosis
- biofilm formation
- single molecule
- high resolution
- endothelial cells
- staphylococcus aureus
- cell cycle arrest
- optical coherence tomography
- oxidative stress
- pseudomonas aeruginosa
- photodynamic therapy
- highly efficient
- wound healing
- essential oil
- cell death
- candida albicans
- pi k akt
- single cell
- electron microscopy