The NARLAL2 dose escalation trial: dosimetric implications of inter-fractional changes in organs at risk.

Lone Hoffmann Marianne Marquard Knap Azza Ahmed KhalilChristina Maria LutzDitte Sloth Møller

Published in: Acta oncologica (Stockholm, Sweden) (2017)

Anatomical changes during radiotherapy caused one or more OAR constraint violations for approximately half of the patient cohort. The main cause was tumour shrinkage. For lung cancer radiotherapy dose escalation trials, we recommend incorporation of adaptive radiotherapy strategies.

Keyphrases

early stage
radiation therapy
locally advanced
radiation induced
open label
clinical trial
rectal cancer
study protocol
phase iii
phase ii
placebo controlled