Novel and deleterious nucleotide variations in the HAND1 gene probably affect miRNA target sites and protein function in pediatric patients with congenital heart disease.

Fateme Tabrizi Mehri Khatami Mohammad Mehdi Heidari José Bragança Hassan Tatari Mohsen Namnabat Mehdi Hadadzadeh Mohammad Ali Navabi Shirazi

Published in: Molecular biology reports (2024)

These findings confirm the phenotypic association between CHDs and HAND1 mutations and can pave the way for developing new preventive and therapeutic strategies.

Keyphrases

copy number
genome wide
protein protein
amino acid
small molecule