Association of APOE-Independent Alzheimer Disease Polygenic Risk Score With Brain Amyloid Deposition in Asymptomatic Older Adults.

Laura Xicota Beata GyorgyBenjamin Grenier-BoleyAlexandre LecoeurGaÃ Lle FontaineFabrice DanjouJorge Samper GonzalezOlivier Colliot Phillippe AmouyelGarance MartinMarcel LevyNicolas Villain Marie-Odile HabertBruno DuboisJean-Charles Lambert Marie-Claude Potiernull null

Published in: Neurology (2022)

PRSs relying on AD genetic risk factors excluding APOE may improve risk prediction for brain amyloid, allowing stratification of cognitively unimpaired individuals at risk of AD independent of their APOE status.

Keyphrases

cognitive decline
mild cognitive impairment
risk factors
high fat diet
resting state
white matter
functional connectivity
physical activity
cerebral ischemia
genome wide
type diabetes
metabolic syndrome
gene expression
dna methylation
copy number
blood brain barrier