Association of common genetic variants with brain microbleeds: A genome-wide association study.
Maria J KnolDongwei LuMatthew TraylorHieab H H AdamsJosé Rafael J RomeroAlbert Vernon SmithMyriam FornageEdith HoferJunfeng LiuIsabel C HostettlerMichelle LucianoStella TrompetAnne-Katrin GieseSaima HilalErik Ben van den AkkerDina VojinovicShuo LiSigurdur SigurdssonSven J van der LeeClifford R JackDuncan WilsonPinar YilmazClaudia L SatizabalDavid C M LiewaldJeroen van der GrondChristopher ChenYasaman SabaAad van der LugtMark E BastinB Gwen WindhamChing Yu ChengLukas PirpamerKejal KantarciJayandra J HimaliQiong YangZoe MorrisAlexa S BeiserDaniel J TozerMeike W VernooijNajaf AminMarian BeekmanJia Yu KohDavid J StottHenry HouldenReinhold SchmidtRebecca F GottesmanAndrew D MacKinnonCharles DeCarliVilmundur GudnasonIan J DearyCornelia M van DuijnP Eline SlagboomTien Yin WongNatalia S RostJ Wouter JukemaThomas H MosleyDavid J WerringHelena SchmidtJoanna Marguerite WardlawM Arfan IkramSudha SeshadriLenore J LaunerHugh S Markusnull nullPublished in: Neurology (2020)
Genetic variants in the APOE region are associated with the presence of BMB, most likely due to the APOE ε4 allele count related to a higher number of strictly lobar BMBs. Genetic predisposition to small vessel disease confers risk of BMB, indicating genetic overlap with other cerebral small vessel disease markers.