Multicenter development of a PET-based risk assessment tool for product-specific outcome prediction in large B-cell lymphoma patients undergoing CAR T-cell therapy.
Conrad-Amadeus VoltinAndrea PaccagnellaMichael WinkelmannJan-Michel HegerBeatrice CasadeiLaura BeckmannKen HerrmannFranziska J DekorsyNadine KutschPeter BorchmannStefano FantiWolfgang G KunzMarion SubkleweCarsten KobePier Luigi ZinzaniMatthias StelljesKatrin S RothAlexander DrzezgaRichard NoppeneyKambiz RahbarH Christian ReinhardtBastian von TresckowRobert SeifertJörn C AlbringViktoria BlumenbergAndrea FarolfiSarah FlossdorfPhilipp GödelChristine HanounPublished in: European journal of nuclear medicine and molecular imaging (2023)
Our analysis demonstrates that the presence of more than one extra-nodal lesion and higher MTV in LBCL are associated with inferior outcome after CAR T-cell treatment. Based on an assessment tool including these two factors, patients can be assigned to one of three risk groups. Importantly, as shown by our study, metabolic tumor burden might facilitate CAR T-cell product selection and reflect the individual need for bridging therapy.
Keyphrases
- cell therapy
- risk assessment
- patients undergoing
- ejection fraction
- stem cells
- newly diagnosed
- mesenchymal stem cells
- lymph node
- prognostic factors
- computed tomography
- diffuse large b cell lymphoma
- pet ct
- neoadjuvant chemotherapy
- heavy metals
- patient reported outcomes
- risk factors
- patient reported
- combination therapy
- double blind
- rectal cancer