Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension.

Steffen D KriechbaumChristoph B WiedenrothKarina PetersMarta A BardeRuth AjnwojnerJan-Sebastian WolterMoritz HaasFritz C RollerStefan GuthAndreas J RiethAndreas RolfChristian W HammEckhard MayerTill KellerChristoph Liebetrau

Published in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2020)

GDF-15 and sST2 levels are higher in CTEPH and identified patients with advanced hemodynamic impairment. Further, decreased GDF-15 levels at follow-up were associated with hemodynamic therapy response. The diagnostic strength was not superior to NT-proBNP.

Keyphrases

pulmonary hypertension
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
stem cells
pulmonary artery
pulmonary arterial hypertension
patient reported outcomes
patient reported