Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune Evasion.

Wenbei PengLinlin YeQianqian XueXiaoshan WeiZihao WangXuan XiangSiyu ZhangPei ZhangHaolei WangQiong Zhou

Published in: Cells (2023)

This study identifies circCRIM1 as a new tumor suppressor that inhibits tumor immune evasion through a competitive combination with IGF2BP1 to destabilize HLA-F mRNA.

Keyphrases

binding protein
small cell lung cancer
pi k akt
growth hormone
gene expression
dna methylation
tyrosine kinase
brain metastases