Cushing Syndrome Is Associated With Gut Microbial Dysbiosis and Cortisol-Degrading Bacteria.
Minchun ZhangZhun ShiChao WuFangming YangTingwei SuXiaohuan JingJuan ShiHuahui RenLei JiangYiran JiangCui ZhangWenzhong ZhouYijing ZhouKui WuSichang ZhengXu ZhongLuming WuWeiqiong GuJie HongJiqiu WangGuang NingRuixin LiuHuanzi ZhongWeiwei ZhouWei-Qing WangPublished in: The Journal of clinical endocrinology and metabolism (2024)
This study provides evidence of gut microbial dysbiosis in patients with CS and identifies a group of CS-enriched bacteria capable of degrading cortisol. These findings highlight the potential role of gut microbiota in regulating host steroid hormone levels, and consequently host health.