Pt-N Coordination Rendering the Chemotherapeutic Agent with Photoactivated ROS Generation and Self-Reporting Cell Uptake.
Shen WangYingcui BuJie ZhangZhipeng YuLianke WangXiaojiao ZhuSen WangHong-Ping ZhouPublished in: ACS applied bio materials (2023)
The performance of chemotherapeutic agents has been largely restrained by the dose-dependent toxic side effects. In this work, cisplatin (CDDP) was endowed with the capability of photoactivated reactive oxygen species (ROS) generation and self-reporting cell uptake via coordination with a small organic molecule MSN . In the resultant MSN-Pt , the Pt-N coordination could obviously enhance the intermolecular charge transfer (ICT) process that allows the integration of fluorescence imaging, photogenerated ROS, and chemotherapeutic performance. The resultant MSN-Pt can recognize between normal and cancer cells and quickly penetrate the cancer cell membrane, self-reporting the cell uptake. Upon light illumination, mitochondria and nuclei were severely damaged. An in vivo mouse model demonstrated that MSN-Pt completely inhibited the tumor growth, exhibiting a higher efficacy compared with that of CDDP. This work provides a facile strategy to develop chemotherapy (CT) drugs for drug-resistant cancers.
Keyphrases
- reactive oxygen species
- drug resistant
- single cell
- cell death
- fluorescence imaging
- mouse model
- multidrug resistant
- adverse drug
- squamous cell carcinoma
- magnetic resonance imaging
- stem cells
- papillary thyroid
- quantum dots
- bone marrow
- gold nanoparticles
- cystic fibrosis
- pseudomonas aeruginosa
- locally advanced
- reduced graphene oxide
- young adults
- positron emission tomography
- water soluble
- pet ct