Lactoferrin Protects Hyperoxia-Induced Lung and Kidney Systemic Inflammation in an In Vivo Imaging Model of NF-κB/Luciferase Transgenic Mice.

Chih-Ching YenWen-Hui ChangMin-Che TungHsiao-Ling ChenHsu-Chung LiuChun-Huei LiaoYing-Wei LanKowit-Yu ChongShang-Hsun YangChuan-Mu Chen

Published in: Molecular imaging and biology (2021)

Our results suggest that hyperoxia can induce systemic inflammation, and the oral administration of LF as a natural antioxidant decreases the production of ROS, attenuates inflammation, and lessens kidney and lung injuries from hyperoxia via the use of live image monitoring of the response in NF-kB/luciferase transgenic mice.

Keyphrases

oxidative stress
diabetic rats
signaling pathway
lps induced
dna damage
pi k akt
nuclear factor
high resolution
high glucose
cell death
deep learning
anti inflammatory
reactive oxygen species
immune response
endothelial cells