Cardiovascular toxicity induced by anti-VEGF/VEGFR agents: a special focus on definitions, diagnoses, mechanisms and management.

Liyu JiangLi PingHao YanXiaochun YangQiaojun HeJiangxin XuPeihua Luo

Published in: Expert opinion on drug metabolism & toxicology (2020)

Cardiovascular toxicity associated with anti-VEGF/VEGFR agents has been a substantial risk for cancer treatment. To improve its management, the development of guidelines for prevention, monitoring and treatment of cardiovascular toxicity has become a hot topic. The summary of cardiovascular toxicity profile, mechanisms and management given in this review is not only significant for the optimal use of existing anti-VEGF/VEGFR agents to protect patients predisposed to cardiovascular toxicity but is also beneficial for drug development.

Keyphrases

endothelial cells
vascular endothelial growth factor
oxidative stress
end stage renal disease
ejection fraction
chronic kidney disease
oxide nanoparticles
prognostic factors
patient reported outcomes