6-Sulfatoxymelatonin predicts treatment response to fluoxetine in major depressive disorder.
Juliana Jury FreitasNicóli Bertuol XavierAndre Comiran TononAlicia CarissimiLeandro Timm PizuttiCarlos Augusto Vieira IlgenfritzRegina Pekelmann MarkusMaria Paz HidalgoPublished in: Therapeutic advances in psychopharmacology (2019)
Nocturnal increase in urinary aMT6s after the first day of medication use links the early mechanism of action of fluoxetine to its clinical output 45 days later. Thus, the relationship between urinary aMT6s excretion 1 day before/1 day after is a biomarker for predicting clinical output earlier, reducing illness burden and health care costs.