Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8+ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes.
Laura Sanz-OrtegaYadileiny PortillaSonia Pérez-YagüeDomingo F BarberPublished in: Journal of nanobiotechnology (2019)
The use of an EMF to improve targeting of tumour-specific T cells modified with APS-MNPs reduced the percentage of these cells infiltrating the tumour, but promoted the retention and the persistence of these cells in the tumour-draining LNs.
Keyphrases
- induced apoptosis
- cell cycle arrest
- mouse model
- lymph node
- cancer therapy
- oxidative stress
- drug delivery
- endoplasmic reticulum stress
- signaling pathway
- squamous cell carcinoma
- mass spectrometry
- young adults
- papillary thyroid
- cell proliferation
- high resolution
- lymph node metastasis
- squamous cell
- liquid chromatography