Prognostic implication of downregulated exosomal miRNAs in patients with sepsis: a cross-sectional study with bioinformatics analysis.
Beomsu ShinJin Young LeeYunjoo ImHongseok YooJunseon ParkJoo Sang LeeKi-Young LeeKyeongman JeonPublished in: Journal of intensive care (2023)
Among the differentially-expressed miRNAs detected in microarrays, the top four downregulated exosomal miRNAs (hsa-let-7f-5p, miR-331-3p miR-301a-3p, and miR-335-5p) were identified as independent prognostic factors for in-hospital and 90-day mortalities among sepsis patients. Bioinformatics analysis demonstrated that these four microRNAs might provide a significant contribution to sepsis pathogenesis through PI3K-Akt and MAPK signaling pathway.
Keyphrases
- pi k akt
- prognostic factors
- signaling pathway
- bioinformatics analysis
- septic shock
- acute kidney injury
- intensive care unit
- cell proliferation
- cell cycle arrest
- end stage renal disease
- epithelial mesenchymal transition
- induced apoptosis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- peritoneal dialysis
- emergency department
- oxidative stress
- risk factors