CSF β-amyloid and white matter damage: a new perspective on Alzheimer's disease.

Anna Margherita PietroboniMarta ScarioniTiziana CarandiniPaola BasilicoMarcello CadioliGiovanni GiuliettiAndrea ArighiMichela CaprioliLaura SerraClara SinaChiara FenoglioLaura GhezziGiorgio G FumagalliMilena A De RizAlberto CalviFabio TriulziMarco BozzaliElio ScarpiniDaniela Galimberti

Published in: Journal of neurology, neurosurgery, and psychiatry (2017)

WM damage is crucial in AD pathogenesis. The correlation between CSF Aβ levels and WM-LL suggests a direct link between amyloid pathology and WM macrostructural and microstructural damage.

Keyphrases

white matter
oxidative stress
multiple sclerosis
cognitive decline
cerebrospinal fluid