Telomerase insufficiency induced telomere erosion accumulation in successive generations in dyskeratosis congenita family.

Caixia HeShuang JingCongling DaiChaofeng TuZhenhua TanJuan DuGuang-Xiu LuGe LinSicong Zeng

Published in: Molecular genetics & genomic medicine (2019)

Our study identified three clinical pathologic TERT mutations and implied that telomere erosion might be accumulated through successive generations, contributing to the severity of DC in the younger generation.

Keyphrases

high glucose
diabetic rats
squamous cell carcinoma
drug induced
oxidative stress
locally advanced
immune response
radiation therapy