Analysis of high-risk pedigrees identifies 11 candidate variants for Alzheimer's disease.

Craig C TeerlinkJustin B MillerElizabeth L VanceLyndsay A StaleyJeffrey StevensJustina P TavanaMatthew E ClowardMadeline L PageLouisa Daytonnull nullLisa A Cannon-AlbrightJohn S K Kauwe

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)

These analyses support ABCA7 and TTR as AD risk genes, expand on previously reported NOTCH3 variant identification, and prioritize seven additional candidate variants.

Keyphrases

copy number
genome wide
bioinformatics analysis
dna methylation
cell proliferation
cognitive decline
gene expression
genome wide identification