Topical tranexamic acid inhibits fibrinolysis more effectively when formulated with self-propelling particles.

James R BaylisMichael M LeeAlexander E St JohnXu WangEric SimonsonMassimo CauAmir KazerooniVionarica GustiMatthew L StatzJeff S J YoonRichard T LigginsNathan J WhiteChristian J Kastrup

Published in: Journal of thrombosis and haemostasis : JTH (2019)

A formulation of TXA that disperses the drug in blood and wounds was effective in several models. It may have several advantages, including supporting local clot stabilization, reducing blood loss from wounds, and providing systemic delivery of TXA. This approach could both improve and simplify prehospital trauma care for penetrating injury.

Keyphrases

trauma patients
wound healing
healthcare
cardiac arrest
palliative care
drug delivery
quality improvement
drug induced
pain management
emergency medical
emergency department
adverse drug