Prenatal glucocorticoid administration enhances bilirubin metabolic capacity and increases Ugt1a and Abcc2 gene expression via glucocorticoid receptor and PXR in rat fetal liver.

Tsukasa Kobayashi Yuko TakebaYuki OhtaMasanori OotakiKeisuke KidaMinoru WatanabeTaroh IiriNaoki Matsumoto

Published in: The journal of obstetrics and gynaecology research (2022)

These results suggest that prenatal GC administration increases bilirubin-metabolic ability, in the premature liver, which may prevent jaundice in neonates.

Keyphrases

gene expression
pregnant women
dna methylation
oxidative stress
mass spectrometry
binding protein
preterm birth
solid phase extraction