Aucklandiae radix targeted PKM2 to alleviate ulcerative colitis: Insights from the photocrosslinking target fishing technique.
Yan-Li FengXin-Rong XuQi-Meng ZhuJing ChangHui-Lin ZhangNa WangJian-Bo SunJing LiuJuan ZhangaCheng-Peng SunPublished in: Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)
AR targeted PKM2 to inhibit NF-κB and NLRP3 pathways, thereby modulating the inflammatory response and immunity to alleviate DSS-induced UC. These findings suggested the potential of AR in the treatment of UC and AR as a candidate for developing PKM2 regulators.