Exploring the link between tumour metabolism and succinate dehydrogenase deficiency: A 18 F-FDOPA PET/CT study in head and neck paragangliomas.

Thibaut ReichertNicolas FakhryJean-Pierre LavieilleVincent AmodruFrédéric SebagPauline RomanetAnderson LoundouFrédéric CastinettiKarel PacakMarion MontavaDavid Taïeb

Published in: Clinical endocrinology (2019)

Our results suggest that SDH deficiency or metastatic behaviour have no influence on 18 F-FDOPA uptake in HNPGL probably due to their very-well differentiation status, even at metastatic stage. The potential prognosticator value of 18 F-FDOPA uptake would need to be further explored in the setting of metastatic PPGL of sympathetic origin.

Keyphrases

pet ct
squamous cell carcinoma
small cell lung cancer
replacement therapy
computed tomography
risk assessment
smoking cessation