Potential Mobilization of mcr-10 by an Integrative Mobile Element via Site-Specific Recombination in Cronobacter sakazakii.
Jing YangLina LiuYu FengDa HeChengcheng WangZhiyong ZongPublished in: Antimicrobial agents and chemotherapy (2021)
mcr-10 is a newly identified plasmid-borne colistin resistance gene, but its mobilization mechanism remains unclear. In this study, mcr-10 was found on an IncFIB plasmid carrying virulence genes mrkABCDFJ, iucABCD/iutA, and eitCBAD in a Cronobacter sakazakii isolate. By comparison with closely related plasmids, two recombination sites were identified flanking the genetic element containing mcr-10 and an integrase-encoding gene, suggesting that site-specific recombination mediated by an integrase of an integrative mobile element is a potential mechanism for mobilizing mcr-10.
Keyphrases
- escherichia coli
- klebsiella pneumoniae
- genome wide
- dna damage
- dna repair
- biofilm formation
- copy number
- genome wide identification
- multidrug resistant
- dna methylation
- gene expression
- transcription factor
- drug resistant
- pseudomonas aeruginosa
- cystic fibrosis
- crispr cas
- candida albicans
- oxidative stress
- gram negative
- acinetobacter baumannii
- drug induced