Epithelial Ovarian Carcinoma Associated with Metastases to Central Nervous System: Two Case Reports.
Yasuyuki KawagoeTetsuo NakayamaSatoshi MatuzawaKazuko FukushimaJunji OnishiYuichiro SatoKimihiro NagaiHiroshi SameshimaPublished in: Case reports in obstetrics and gynecology (2018)
We experienced two rare cases of metastases to the central nervous system (cerebral and leptomeningeal metastases) from primary epithelial ovarian carcinoma. The first case was a 55-year-old woman who developed carcinomatous meningitis while on chemotherapy for ovarian cancer stage IIIC. Cytological analysis confirmed carcinomatous cells of ovarian origin in the cerebrospinal fluid. Magnetic resonance imaging demonstrated abnormal hyperintensity in the cerebral sulci on fluid attenuated inversion recovery (FLAIR) sequence with enhanced gadolinium indicating leptomeningeal metastases. Her consciousness rapidly declined and she died 42 days after diagnosis. The second case was a 63-year-old woman who underwent surgery for ovarian cancer and who was diagnosed as stage IA. Thirty-eight months after surgery, she developed weakness of the left hand and headaches. A CT scan revealed metastases to the right cerebrum and she was treated with surgical resection followed by radiotherapy. Five months after resection, she developed ileus caused by multiple relapses in the pelvis. Despite chemotherapy, her performance status declined and she died nine months after the resection. Both cases were rare because the first case was isolated leptomeningeal metastases, and the second case was confirmed relapse site in the cerebrum due to neurological symptoms despite her early clinical stage.
Keyphrases
- cerebrospinal fluid
- magnetic resonance imaging
- computed tomography
- contrast enhanced
- locally advanced
- subarachnoid hemorrhage
- early stage
- minimally invasive
- squamous cell carcinoma
- coronary artery bypass
- image quality
- positron emission tomography
- newly diagnosed
- cell cycle arrest
- percutaneous coronary intervention
- cell proliferation
- physical activity
- cerebral blood flow
- dual energy
- depressive symptoms
- chemotherapy induced
- radiation induced
- atrial fibrillation
- diffusion weighted imaging