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Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis.

Eiichi TokudaYo-Ichi TakeiShinji OharaNoriko FujiwaraIsao HozumiYoshiaki Furukawa
Published in: Molecular neurodegeneration (2019)
Taken together, we propose that misfolding of wild-type SOD1 in CSF is a common pathological process of ALS cases regardless of SOD1 mutations.
Keyphrases
  • amyotrophic lateral sclerosis
  • wild type
  • cerebrospinal fluid
  • heavy metals
  • nitric oxide
  • late onset
  • early onset