Co-introduction of plasmids harbouring the carbapenemase genes, blaNDM-1 and blaOXA-232, increases fitness and virulence of bacterial host.
Haejeong LeeJuyoun ShinYeun-Jun ChungMyungseo ParkKyeong Jin KangJin Yang BaekDongwoo ShinDoo Ryeon ChungKyong Ran PeckJae-Hoon SongKwan Soo KoPublished in: Journal of biomedical science (2020)
Our data indicate that bacteria carrying multiple plasmids encoding different carbapenemases may have increased fitness and virulence, emphasizing the need for diverse strategies to combat antimicrobial resistance.
Keyphrases
- klebsiella pneumoniae
- antimicrobial resistance
- escherichia coli
- multidrug resistant
- body composition
- physical activity
- genome wide
- electronic health record
- drug resistant
- acinetobacter baumannii
- big data
- gram negative
- staphylococcus aureus
- genome wide identification
- pseudomonas aeruginosa
- cystic fibrosis
- bioinformatics analysis
- machine learning
- data analysis
- artificial intelligence
- genome wide analysis