Heart Size Difference Drives Sex-Specific Response to Cardiac Resynchronization Therapy: A Post Hoc Analysis of the MORE-MPP CRT Trial.
Nadeev WijesuriyaVishal Shahil MehtaFelicity De VereSandra HowellSteven A NiedererHaran Burri FehraJohannes SperzelLeonardo CalòBernard ThibaultWenjiao LinKwangdeok LeeAndrea GrammaticoNiraj VarmaMarianne GwechenbergerChristophe LeclercqChristopher A RinaldiPublished in: Journal of the American Heart Association (2024)
In the nonischemic cardiomyopathy left bundle-branch block population, increased relative dyssynchrony in women, who have smaller heart sizes than their male counterparts, is a driver of sex-specific CRT response, particularly at QRSd <150 ms. Women may benefit from CRT at a QRSd <130 ms, opening the debate on whether sex-specific QRSd cutoffs or QRS/LVEDV measurement should be incorporated into clinical guidelines.
Keyphrases
- cardiac resynchronization therapy
- heart failure
- left ventricular
- polycystic ovary syndrome
- mass spectrometry
- multiple sclerosis
- ms ms
- pregnancy outcomes
- atrial fibrillation
- cervical cancer screening
- clinical trial
- clinical practice
- study protocol
- pregnant women
- insulin resistance
- type diabetes
- metabolic syndrome
- phase ii
- adipose tissue