Role of variant allele fraction and rare SNP filtering to improve cellular DNA repair endpoint association.
David M VossenCaroline V M VerhagenReidar GrénmanRoelof J C KluinMarcel VerheijMichiel W M van den BrekelLodewyk F A WesselsConchita VensPublished in: PloS one (2018)
Together our data show that the detection of relevant genes or of repair pathway defected tumor cells can be improved by the consideration of allele zygosity and SNP allele frequencies.