The rs3761548 FOXP3 variant is associated with multiple sclerosis and transforming growth factor β1 levels in female patients.

Tamires FlauzinoDaniela Frizon AlfieriWildea Lice de Carvalho Jennings PereiraSayonara Rangel OliveiraAna Paula KallaurMarcell Alysson Batisti LozovoyDamacio Ramón Kaimen-MacielKaren Brajão de OliveiraAndrea Name Colado SimãoEdna Maria Vissoci Reiche

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)

These results suggest that the A allele of FOXP3 -3279 C > A variant may exert a role in the T regulatory cell function, which could be one of the factors involved in the susceptibility for MS in females.

Keyphrases

multiple sclerosis
transforming growth factor
regulatory t cells
end stage renal disease
epithelial mesenchymal transition
ejection fraction
newly diagnosed
chronic kidney disease
mass spectrometry
prognostic factors
ms ms
transcription factor
immune response
signaling pathway